The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world.
Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells …

The increase in global lifespan has in turn increased the prevalence of osteoarthritis which
is now the most common type of arthritis. Cartilage tissue located on articular joints erodes …

The neural crest is a stem/progenitor cell population that contributes to a wide variety of
derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and …

Decades of work have identified the signaling pathways that regulate the differentiation of
chondrocytes during bone formation, from their initial induction from mesenchymal …

Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

Chondrogenesis is a highly coordinated event in embryo development, adult homeostasis,
and repair of the vertebrate cartilage. Fate decisions and differentiation of chondrocytes …

The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …