The kainic acid models of temporal lobe epilepsy

E Rusina, C Bernard, A Williamson - Eneuro, 2021 - eneuro.org
Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

Lasting differential effects on plasticity induced by prenatal stress in dorsal and ventral hippocampus

G Grigoryan, M Segal - Neural Plasticity, 2016 - Wiley Online Library
Early life adversaries have a profound impact on the developing brain structure and
functions that persist long after the original traumatic experience has vanished. One of the …

Reference gene validation in the brain regions of young rats after pentylenetetrazole-induced seizures

AP Schwarz, AA Kovalenko, DA Malygina… - Biomedicines, 2020 - mdpi.com
Reverse transcription followed by quantitative polymerase chain reaction (qRT-PCR) is a
powerful and commonly used tool for gene expression analysis. It requires the right choice …

Multimodal characterization of neural networks using highly transparent electrode arrays

MJ Donahue, A Kaszas, GF Turi, B Rózsa, A Slézia… - Eneuro, 2018 - eneuro.org
Transparent and flexible materials are attractive for a wide range of emerging bioelectronic
applications. These include neural interfacing devices for both recording and stimulation …

[HTML][HTML] Identification of Reliable Reference Genes for Use in Gene Expression Studies in Rat Febrile Seizure Model

AA Kovalenko, MV Zakharova… - International …, 2024 - pmc.ncbi.nlm.nih.gov
The study of the pathogenesis of febrile seizures and their consequences frequently
necessitates gene expression analysis. The primary methodology employed for such …

Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice

MA Luque, S Morcuende, B Torres… - The Journal of …, 2024 - Wiley Online Library
Fragile X syndrome (FXS), the most frequent monogenic form of intellectual disability, is
caused by transcriptional silencing of the FMR1 gene that could render neuronal …

Distinct Ventral Hippocampus Network Properties in Dissociated Cultures

M Segal - Hippocampus, 2024 - Wiley Online Library
Extensive research has been focused in the past century on structural, physiological, and
molecular attributes of the hippocampus. This interest was created by the unique …

Analysis of the Effects of Pentose Phosphate Pathway Inhibition on the Generation of Reactive Oxygen Species and Epileptiform Activity in Hippocampal Slices

D Ponomareva, A Ivanov, P Bregestovski - International Journal of …, 2024 - mdpi.com
The pentose phosphate pathway (PPP) is one of three major pathways involved in glucose
metabolism, which is regulated by glucose-6-phosphate dehydrogenase (G6PD) controls …

Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg2+, Ca2+, and K+

H Liu, S Zhang, L Zhang - BMC neuroscience, 2021 - Springer
Background Rodent brain slices—particularly hippocampal slices—are widely used in
experimental investigations of epileptiform activity. Oxygenated artificial cerebrospinal fluid …

Trajectories of brain remodeling in temporal lobe epilepsy

E Roggenhofer, E Santarnecchi, S Muller, F Kherif… - Journal of …, 2019 - Springer
Temporal lobe epilepsy has been usually associated with progressive brain atrophy due to
neuronal cell loss. However, recent animal models demonstrated a dual effect of epileptic …