As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and
adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) …

Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states.
Previous genetic studies have largely focused on insulin resistance in the fasting state …

Elective surgery causes a marked, transient reduction in insulin sensitivity. The degree of the
reduction is related to the magnitude of the operation. The type and duration of surgery …

Total GLUT4 content in skeletal muscle from individuals with type 2 diabetes is normal;
however, recent studies have demonstrated that translocation of GLUT4 to the plasma …

Fatty acid oxidation is highly regulated in skeletal muscle and involves several sites of
regulation, including the transport of fatty acids across both the plasma and mitochondrial …

Studies in rodents have established that GLUT-4 translocation is the major mechanism by
which insulin and exercise increase glucose uptake in skeletal muscle. In contrast, much …

Cell surface GLUT4 levels in skeletal muscle from nine type 2 diabetic subjects and nine
healthy control subjects have been assessed by a new technique that involves the use of a …

The purpose of this study was to determine the efficacy of glutamine in promoting whole
body carbohydrate storage and muscle glycogen resynthesis during recovery from …