Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells.
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …

Gastrointestinal motility results from coordinated contractions of the tunica muscularis, the
muscular layers of the alimentary canal. Throughout most of the gastrointestinal tract …

Covers all aspects of the structure, function, neurochemistry, transmitter identification and
development of the enteric nervous system This book brings together extensive knowledge …

Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

▪ Abstract In the gastrointestinal tract, phasic contractions are caused by electrical activity
termed slow waves. Slow waves are generated and actively propagated by interstitial cells …

Interstitial cells of Cajal (ICC) generate pacemaker activity (slow waves) in gastrointestinal
(GI) smooth muscles, but the mechanism (s) of pacemaker activity are controversial. Several …

Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal
neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit …

Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as
gastroparesis. These disorders typically include debilitating symptoms, such as chronic …

Regulation of smooth muscle contractility is essential for many important biological
processes such as tissue perfusion, cardiovascular haemostasis and gastrointestinal …

The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …