The pleiotropic effects of creatine (Cr) are based mostly on the functions of the enzyme
creatine kinase (CK) and its high-energy product phosphocreatine (PCr). Multidisciplinary …

Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic
cells′ life. Up to the 1990s of the past century, ROS have been solely considered as toxic …

Creatine is physiologically provided equally by diet and by endogenous synthesis from
arginine and glycine with successive involvements of arginine glycine amidinotransferase …

Oxidative stress is the result of an imbalance between the generation of reactive oxygen
species (ROS) and their elimination by antioxidant mechanisms. ROS degrade biogenic …

Athletes, body builders, and military personnel use dietary creatine as an ergogenic aid to
boost physical performance in sports involving short bursts of high-intensity muscle activity …

Tuberculosis (TB) is one of three major infectious diseases, and the control of TB is
becoming more difficult because of the emergence of multidrug-resistant and extensively …

High-fat (HF) diets in combination with sedentary lifestyle represent one of the major public
health concerns predisposing to obesity and diabetes leading to skeletal muscle atrophy …

Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving
greater attention because of its beneficial effects in a wide number of human degenerative …

Creatine is a nitrogenous organic acid that plays a central role as an energy buffer in high
energy demanding systems, including the muscular and the central nervous system. It can …

Respiratory conditions such as chronic obstructive pulmonary disease (COPD) are
associated with a greater risk for lung cancer (LC). Oxidative stress and inflammation are …