Molecular iodine-mediated cyclization of tethered heteroatom-containing alkenyl or alkynyl systems

MJ Mphahlele - Molecules, 2009 - mdpi.com
Molecular iodine has established itself as a readily available and easy-to-handle
electrophilic and oxidizing reagent used in various organic transformations. In this review …

Recent Advances in the Catalytic Synthesis of the Cyclopentene Core

R Miguélez, P Barrio, JM González - The Chemical Record, 2023 - Wiley Online Library
Five‐membered carbocycles are ubiquitously found in natural products, pharmaceuticals,
and other classes of organic compounds. Within this category, cyclopentenes deserve …

Competition studies in alkyne electrophilic cyclization reactions

S Mehta, JP Waldo, RC Larock - The Journal of organic chemistry, 2009 - ACS Publications
The relative reactivity of various functional groups toward alkyne electrophilic cyclization
reactions has been studied. The required diarylalkynes have been prepared by consecutive …

Photocatalytic sulfonylcarbocyclization of alkynes using SEt as a traceless directing group: access to cyclopentenes and indenes

Y Zhou, Y Qin, Q Wang, Z Zhang, G Zhu - Angewandte Chemie, 2022 - Wiley Online Library
Cyclopentenes and indenes are important structural scaffolds in synthetic, medical, and
material chemistry. Cyclization of alkynes via remote C− H functionalization is an appealing …

Alkyne activation with Brønsted acids, iodine, or gold complexes, and its fate leading to synthetic application

Y Yamamoto, ID Gridnev, NT Patil, T Jin - Chemical communications, 2009 - pubs.rsc.org
The reaction of 2-alkynyl-1-methylene azide aromatics 1 with iodine gives 1, 3-disubstituted
4-iodoisoquinolines 3, and the treatment of 1 with a gold–silver combined catalyst affords …

Iodine/palladium approaches to the synthesis of polyheterocyclic compounds

S Mehta, RC Larock - The Journal of organic chemistry, 2010 - ACS Publications
A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is
reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling …

Synthesis of cyclopentene derivatives via electrochemically induced intermolecular selective (3+ 2) annulation

Z Guan, S Zhu, Y Ye, X Li, Y Liu, P Wang… - Angewandte …, 2022 - Wiley Online Library
Cyclopentenes are common cores in many natural products, and in bioactive and functional
molecules. However, their synthesis remains challenging in terms of harsh conditions, poor …

Intramolecular ipso-Halocyclization of 4-(p-Unsubstituted-aryl)-1-alkynes Leading to Spiro[4,5]trienones: Scope, Application, and Mechanistic Investigations

BX Tang, YH Zhang, RJ Song, DJ Tang… - The Journal of …, 2012 - ACS Publications
A new, general method for the synthesis of spiro [4, 5] trienones is described by the
intramolecular ipso-halocyclization of 4-(p-unsubstituted-aryl)-1-alkynes. In the presence of …

A Simple and Mild Synthesis of 1H-Isochromenes and (Z)-1-Alkylidene-1,3-dihydroisobenzofurans by the Iodocyclization of 2-(1-Alkynyl)benzylic Alcohols

R Mancuso, S Mehta, B Gabriele… - The Journal of …, 2010 - ACS Publications
A variety of iodo-substituted isochromenes, dihydroisobenzofurans, and pyranopyridines are
readily prepared in good to excellent yields under mild conditions by the iodocyclization of …

Facile synthesis of carbazoles via a tandem iodocyclization with 1, 2-alkyl migration and aromatization

J Wang, HT Zhu, YF Qiu, Y Niu, S Chen, YX Li… - Organic …, 2015 - ACS Publications
A strategy for the synthesis of iodocarbazoles through a tandem iodocyclization with
migration and aromatization is presented. This sequential cascade process is concisely …