Estradiol is a steroid hormone that not only plays an important role in ovarian follicular
development but also is associated with many reproductive disorders. Owing to the …

In the last few decades, stem cell therapy has grown as a boon for many pathological
complications including female reproductive disorders. In this review, a brief description of …

Very small embryonic‐like cells (VSELs), found in murine bone marrow and other adult
tissues, are small, non‐hematopoietic cells expressing markers of pluripotent embryonic and …

The female reproductive lifespan is largely determined by the size of primordial follicle pool,
which is established following germ cell cyst breakdown around birth. Almost two-third of …

Background Microenvironment signals play a critical role in directing the differentiation of
stem cells. Sertoli cells (SCs) provide a unique microenvironment that is essential for germ …

Evidence of germ cell derivation from embryonic and somatic stem cells provides an in vitro
model for the study of germ cell development, associated epigenetic modification and …

Contents Several studies have proposed that in vitro generation of germ cells (GC s) from
stem cells can be considered a future option for infertility treatment. Mesenchymal stem cells …

Previous reports have demonstrated that embryonic stem cells were capable of
differentiating into primordial germ cells through the formation of embryoid bodies that …

The present study evaluated the alkaline phosphatase activity, cell cycle stage, expression
of markers and early transcriptional factors, and in vitro differentiation into selected cell …

We previously reported the differentiation of cells derived from porcine female fetal skin into
cells resembling germ cells and oocytes. A subpopulation of these cells expressed germ cell …