m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins
The control of gene expression is a multi-layered process occurring at the level of DNA,
RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA …
RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA …
The m6A Writer: Rise of a Machine for Growing Tasks
DL Balacco, M Soller - Biochemistry, 2018 - ACS Publications
The central dogma of molecular biology introduced by Crick describes a linear flow of
information from DNA to mRNA to protein. Since then it has become evident that RNA …
information from DNA to mRNA to protein. Since then it has become evident that RNA …
Nuclear mRNA decay: regulatory networks that control gene expression
Proper regulation of mRNA production in the nucleus is critical for the maintenance of
cellular homoeostasis during adaptation to internal and environmental cues. Over the past …
cellular homoeostasis during adaptation to internal and environmental cues. Over the past …
The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay
Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+)
RNA is facilitated by the Poly (A) Tail eXosome Targeting (PAXT) connection. Besides its …
RNA is facilitated by the Poly (A) Tail eXosome Targeting (PAXT) connection. Besides its …
Chromosome-associated RNA–protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe
DQ Ding, K Okamasa, Y Katou, E Oya… - Nature …, 2019 - nature.com
Pairing of homologous chromosomes in meiosis is essential for sexual reproduction. We
have previously demonstrated that the fission yeast sme2 RNA, a meiosis-specific long …
have previously demonstrated that the fission yeast sme2 RNA, a meiosis-specific long …
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast
RA Varier, T Sideri, C Capitanchik, Z Manova… - Elife, 2022 - elifesciences.org
Abstract N6-methyladenosine (m6A) RNA modification impacts mRNA fate primarily via
reader proteins, which dictate processes in development, stress, and disease. Yet little is …
reader proteins, which dictate processes in development, stress, and disease. Yet little is …
A scaffold lncRNA shapes the mitosis to meiosis switch
Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression in
response to intra-or extracellular signals but the underlying molecular mechanisms remain …
response to intra-or extracellular signals but the underlying molecular mechanisms remain …
Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex
AE Foucher, L Touat-Todeschini… - Nature …, 2022 - nature.com
To eliminate specific or aberrant transcripts, eukaryotes use nuclear RNA-targeting
complexes that deliver them to the exosome for degradation. S. pombe MTREC, and its …
complexes that deliver them to the exosome for degradation. S. pombe MTREC, and its …
Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes
can become dispensable for viability remain unclear. Here, we investigate 'bypass of …
can become dispensable for viability remain unclear. Here, we investigate 'bypass of …
A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
Gene regulatory mechanisms rely on a complex network of RNA processing factors to
prevent untimely gene expression. In fission yeast, the highly conserved ortholog of human …
prevent untimely gene expression. In fission yeast, the highly conserved ortholog of human …