Compressive stresses in cancer: characterization and implications for tumour progression and treatment
JA Linke, LL Munn, RK Jain - Nature Reviews Cancer, 2024 - nature.com
Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …
abnormal physical microenvironment that fuels cancer progression and confers treatment …
Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation
Cell surface and intracellular mechanosensors enable cells to perceive different geometric,
topographical, and physical cues. Mechanosensitive ion channels (MICs) localized at the …
topographical, and physical cues. Mechanosensitive ion channels (MICs) localized at the …
Confinement controls the directional cell responses to fluid forces
Our understanding of how fluid forces influence cell migration in confining environments
remains limited. By integrating microfluidics with live-cell imaging, we demonstrate that cells …
remains limited. By integrating microfluidics with live-cell imaging, we demonstrate that cells …
Hippo signaling modulation and its biological implications in urological malignancies
T Tong, M Huang, B Yan, B Lin, J Yu, Q Teng… - Molecular Aspects of …, 2024 - Elsevier
Although cancer diagnosis and treatment have rapidly advanced in recent decades,
urological malignancies, which have high morbidity and mortality rates, are among the most …
urological malignancies, which have high morbidity and mortality rates, are among the most …
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the
contribution of genetic and epigenetic modifications to breast cancer progression has been …
contribution of genetic and epigenetic modifications to breast cancer progression has been …
Leveraging Cell Migration Dynamics to Discriminate Between Senescent and Presenescent Human Mesenchymal Stem Cells
F Amiri, P Mistriotis - Cellular and Molecular Bioengineering, 2024 - Springer
Purpose The suboptimal clinical performance of human mesenchymal stem cells (hMSCs)
has raised concerns about their therapeutic potential. One major contributing factor to this …
has raised concerns about their therapeutic potential. One major contributing factor to this …
Differential effects of confinement‐induced reactive oxygen species accumulation on highly motile cancerous and non‐cancerous cells
In vivo, migrating cells often encounter microenvironments that impose spatial constraints,
leading to cell and nuclear deformation. As confinement‐induced DNA damage has been …
leading to cell and nuclear deformation. As confinement‐induced DNA damage has been …