Resistance integrons: class 1, 2 and 3 integrons

Y Deng, X Bao, L Ji, L Chen, J Liu, J Miao… - Annals of clinical …, 2015 - Springer
As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary
treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for …

Integrons: agents of bacterial evolution

D Mazel - Nature Reviews Microbiology, 2006 - nature.com
Integrons are assembly platforms—DNA elements that acquire open reading frames
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …

Integrons

G Cambray, AM Guerout, D Mazel - Annual review of genetics, 2010 - annualreviews.org
Integrons are genetic elements able to acquire and rearrange open reading frames (ORFs)
embedded in gene cassette units and convert them to functional genes by ensuring their …

Gene cassettes and cassette arrays in mobile resistance integrons

SR Partridge, G Tsafnat, E Coiera… - FEMS microbiology …, 2009 - academic.oup.com
Gene cassettes are small mobile elements, consisting of little more than a single gene and
recombination site, which are captured by larger elements called integrons. Several …

[HTML][HTML] Resistance integrons and super-integrons

AC Fluit, FJ Schmitz - Clinical microbiology and infection, 2004 - Elsevier
Integrons are genetic elements composed of a gene encoding an integrase, gene cassettes
and an integration site for the gene cassettes (att). The integrase excises and integrates the …

Integrons in the development of antimicrobial resistance: critical review and perspectives

BA Bhat, RA Mir, H Qadri, R Dhiman… - Frontiers in …, 2023 - frontiersin.org
Antibiotic resistance development and pathogen cross-dissemination are both considered
essential risks to human health on a worldwide scale. Antimicrobial resistance genes …

The integron: adaptation on demand

JA Escudero, C Loot, A Nivina, D Mazel - Microbiology spectrum, 2015 - Am Soc Microbiol
The integron is a powerful system which, by capturing, stockpiling, and rearranging new
functions carried by gene encoding cassettes, confers upon bacteria a rapid adaptation …

Folded DNA in action: hairpin formation and biological functions in prokaryotes

D Bikard, C Loot, Z Baharoglu… - … and Molecular Biology …, 2010 - Am Soc Microbiol
Structured forms of DNA with intrastrand pairing are generated in several cellular processes
and are involved in biological functions. These structures may arise on single-stranded DNA …

Structural basis for broad DNA-specificity in integron recombination

D MacDonald, G Demarre, M Bouvier, D Mazel… - Nature, 2006 - nature.com
Lateral DNA transfer—the movement of genetic traits between bacteria—has a profound
impact on genomic evolution and speciation. The efficiency with which bacteria incorporate …

Class 1 integron in staphylococci

Z Xu, L Li, L Shi, ME Shirtliff - Molecular biology reports, 2011 - Springer
As a major concern in public health, methicillin-resistant staphylococci (MRS) still remains
one of the most prevalent pathogens that cause nosocomial infections throughout the world …