Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

LH Wong, AT Gatta, TP Levine - Nature reviews Molecular cell biology, 2019 - nature.com
Lipids are distributed in a highly heterogeneous fashion in different cellular membranes.
Only a minority of lipids achieve their final intracellular distribution through transport by …

Early steps in steroidogenesis: intracellular cholesterol trafficking: thematic review series: genetics of human lipid diseases

WL Miller, HS Bose - Journal of lipid research, 2011 - ASBMB
Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

Selective release of microRNA species from normal and malignant mammary epithelial cells

L Pigati, SCS Yaddanapudi, R Iyengar, DJ Kim… - PloS one, 2010 - journals.plos.org
MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose …

Genome-wide analysis of DNA copy-number changes using cDNA microarrays

JR Pollack, CM Perou, AA Alizadeh, MB Eisen… - Nature …, 1999 - nature.com
Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization
of these DNA copy-number changes is important for both the basic understanding of cancer …

Cholesterol transport in steroid biosynthesis: Role of protein–protein interactions and implications in disease states

MB Rone, J Fan, V Papadopoulos - … Acta (BBA)-Molecular and Cell Biology …, 2009 - Elsevier
The transfer of cholesterol from the outer to the inner mitochondrial membrane is the rate-
limiting step in hormone-induced steroid formation. To ensure that this step is achieved …

Give lipids a START: the StAR-related lipid transfer (START) domain in mammals

F Alpy, C Tomasetto - Journal of cell science, 2005 - journals.biologists.com
The steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain is a
protein module of∼ 210 residues that binds lipids, including sterols. Fifteen mammalian …

Amplification and deletion of topoisomerase IIα associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer

TAH Järvinen, M Tanner, V Rantanen… - The American journal of …, 2000 - Elsevier
Topoisomerase IIα (topoIIα) is a key enzyme in DNA replication and a molecular target for
many anti-cancer drugs called topoII inhibitors. The topoIIα gene is located at chromosome …

New genes involved in cancer identified by retroviral tagging

T Suzuki, H Shen, K Akagi, HC Morse, JD Malley… - Nature …, 2002 - nature.com
Retroviral insertional mutagenesis in BXH2 and AKXD mice induces a high incidence of
myeloid leukemia and B-and T-cell lymphoma, respectively. The retroviral integration sites …

StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism

RE Soccio, JL Breslow - Journal of Biological Chemistry, 2003 - ASBMB
StAR-related lipid transfer (START) 1 domains are 210-amino acid lipid binding domains
implicated in intracellular lipid transport, lipid metabolism, and cell signaling events. The …

Alteration of topoisomerase II–alpha gene in human breast cancer: Association with responsiveness to anthracycline-based chemotherapy

MF Press, G Sauter, M Buyse, L Bernstein… - Journal of Clinical …, 2011 - ascopubs.org
Purpose Approximately 35% of HER2-amplified breast cancers have coamplification of the
topoisomerase II-alpha (TOP2A) gene encoding an enzyme that is a major target of …