Great progress has been made over the past years in elucidating the structure and function
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …

Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

The nonstructural 5A (NS5A) protein is a target for drug development against hepatitis C
virus (HCV). Interestingly, the NS5A inhibitor daclatasvir (BMS-790052) caused a decrease …

Hepatitis C virus (HCV) is a significant pathogen, infecting some 170 million people
worldwide. Persistent virus infection often leads to cirrhosis and liver cancer. In the infected …

ABSTRACT BMS-790052 is the most potent hepatitis C virus (HCV) inhibitor reported to
date, with 50% effective concentrations (EC50s) of≤ 50 pM against genotype 1 replicons …

ABSTRACT A new protein expression vector design utilizing an N-terminal six-histidine tag
and tobacco etch virus protease cleavage site upstream of the hepatitis C virus NS5A …

Positive strand RNA viruses replicate in the cytoplasm of infected cells and induce
intracellular membranous compartments harboring the sites of viral RNA synthesis. These …

Hijacking and manipulation of host cell biosynthetic pathways by human enveloped viruses
are essential for the viral lifecycle. Flaviviridae members, including hepatitis C, dengue and …

The hepatitis C viral (HCV) genome is translated through an internal ribosome entry site
(IRES) as a single polyprotein precursor that is subsequently cleaved into individual mature …

Highlights•HCV NS5A replication complex inhibitors.•Exceptional potency with broad
genotype coverage translated in clinical studies.•Important component for HCV combination …