Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
J Nijssen, LH Comley, E Hedlund - Acta neuropathologica, 2017 - Springer
In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …
The sigma-1 receptor as a pluripotent modulator in living systems
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
Crystal structure of the human σ1 receptor
The human σ1 receptor is an enigmatic endoplasmic-reticulum-resident transmembrane
protein implicated in a variety of disorders including depression, drug addiction, and …
protein implicated in a variety of disorders including depression, drug addiction, and …
Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis
DA Rosen, SM Seki, A Fernández-Castañeda… - Science translational …, 2019 - science.org
Sepsis is an often deadly complication of infection in which systemic inflammation damages
the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the …
the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the …
[HTML][HTML] Neuronal sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
DA Ryskamp, S Korban, V Zhemkov… - Frontiers in …, 2019 - frontiersin.org
Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
Sigmar1's molecular, cellular, and biological functions in regulating cellular pathophysiology
The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases
The sigma-1 (σ1) receptor, an enigmatic protein originally classified as an opioid receptor
subtype, is now understood to possess unique structural and functional features of its own …
subtype, is now understood to possess unique structural and functional features of its own …
The role of sigma-1 receptor, an intracellular chaperone in neurodegenerative diseases
B Penke, L Fulop, M Szucs… - Current …, 2018 - ingentaconnect.com
Background: Widespread protein aggregation occurs in the living system under stress or
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
Abstract The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the
mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and …
mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and …
Mitochondrial complex 1, sigma 1, and synaptic vesicle 2A in early drug‐naive Parkinson's disease
H Wilson, G Pagano, ER de Natale… - Movement …, 2020 - Wiley Online Library
Background Dysfunction of mitochondrial energy generation may contribute to
neurodegeneration, leading to synaptic loss in Parkinson's disease (PD). The objective of …
neurodegeneration, leading to synaptic loss in Parkinson's disease (PD). The objective of …