The endoplasmic reticulum (ER) plays a critical role in the synthesis and chaperoning of
membrane-associated and secreted proteins. The membrane is also an important site of …

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …

Work performed with differentiated contractile smooth muscle tissue over the last two
decades has made clear that covalent modification of myosin by phosphorylation of the 20 …

The endoplasmic reticulum (ER) in animal cells is an extensive, morphologically continuous
network of membrane tubules and flattened cisternae. The ER is a multifunctional organelle; …

The ryanodine receptor (RyR) is a high-conductance Ca2+ channel of the sarcoplasmic
reticulum in muscle and of the endoplasmic reticulum in other cells. In striated muscle fibers …

Calreticulin is a ubiquitous Ca2+ binding protein, located in the endoplasmic reticulum
lumen, which has been implicated in many diverse functions including: regulation of …

The endoplasmic reticulum (ER) and its specialized subcompartments such as the
sarcoplasmic reticulum, is the main dynamic Ca 2+ storage compartment of the cell. Key …

▪ Abstract An unconventional mechanism for retaining improperly folded glycoproteins and
facilitating acquisition of their native tertiary and quaternary structures operates in the …

INTRODUCTION In eukaryotic cells, a large fraction of the proteins syn-thesized acquire
oneor more N-linked oligosaccharides. These are added as core oligosaccharide units to …

Background Previous studies provide considerable evidence that excitation-contraction
coupling may be disturbed at the level of the sarcoplasmic reticulum (SR) in the failing …