The cellular basis of fibrotic tendon healing: challenges and opportunities

AEC Nichols, KT Best, AE Loiselle - Translational Research, 2019 - Elsevier
Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

Diagnosis and management of partial thickness rotator cuff tears: a comprehensive review

KD Plancher, J Shanmugam, K Briggs… - JAAOS-Journal of the …, 2021 - journals.lww.com
Partial thickness rotator cuff tears (PRCTs) are a challenging disease entity. Optimal
management of PRCTs continues to be controversial. Although advances in magnetic …

Retracted rotator cuff repairs heal with disorganized fibrogenesis without affecting biomechanical properties: a comparative animal model study

SM Rhee, SM Youn, YW Ko, TY Kwon, YK Park… - … : The Journal of …, 2021 - Elsevier
Purpose To determine the differences in the scar tissue formation during the healing of the
repaired retracted cuff tear from that of the nonretracted tear. Methods Eighteen right rabbit …

Overload in a rat in vivo model of synergist ablation induces tendon multiscale structural and functional degeneration

ET Bloom, LM Lin, RC Locke… - Journal of …, 2023 - asmedigitalcollection.asme.org
Tendon degeneration is typically described as an overuse injury with little distinction made
between magnitude of load (overload) and number of cycles (overuse). Further, in vivo …

Establishing in vivo and ex vivo chick embryo models to investigate fetal tendon healing

PK Nguyen, C Hart, K Hall, I Holt, CK Kuo - Scientific Reports, 2023 - nature.com
Injured adult tendons heal fibrotically and possess high re-injury rates, whereas fetal
tendons appear to heal scarlessly. However, knowledge of fetal tendon wound healing is …

Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing

BY Shi, V Sriram, SY Wu, D Huang… - … in Bioengineering and …, 2024 - frontiersin.org
Background: Osteoadsorptive fluorogenic sentinel 3 (OFS-3) is a recently described
compound that contains a bone-targeting bisphosphonate (BP) and cathepsin K (Ctsk) …

Nontendinous healing after repairing of retracted rotator cuff tear: an imaging study

SM Youn, YG Rhee, SM Rhee - Journal of Shoulder and Elbow Surgery, 2021 - Elsevier
Background Follow-up magnetic resonance imaging (MRI) after rotator cuff repair can
sometimes demonstrate healing with nontendinous tissue that extends from the footprint to …

Success criteria and preclinical testing of multifunctional hydrogels for tendon regeneration

RC Locke, EM Ford, KG Silbernagel… - … Engineering Part C …, 2020 - liebertpub.com
Tendon injuries are difficult to heal, in part, because intrinsic tendon healing, which is
dominated by scar tissue formation, does not effectively regenerate the native structure and …

Toxic effects of local anesthetics on rat fibroblasts: An in-vitro study

KM Hones, KA Hao, JO Wright, TW Wright… - Journal of Orthopaedic …, 2024 - Elsevier
Background Infusion catheters facilitate a controlled infusion of local anesthetic (LA) for pain
control after surgery. However, their potential effects on healing fibroblasts are unspecified …

Partial infraspinatus tendon transection as a means for the development of a translational ovine chronic rotator cuff disease model

J Easley, J Johnson, D Regan, E Hackett… - Veterinary and …, 2020 - thieme-connect.com
Objective Rotator cuff tendon tears are the most common soft tissue injuries in the shoulder
joint. Various animal models have been described for this condition, but all current …