Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in
even more detail, by the 24-hour urine steroid metabolome, which can provide unique …

Steroids are complex lipophilic molecules that have many actions in the body to regulate
cellular, tissue and organ functions across the life-span. Steroid hormones such as cortisol …

Differences/disorders of sex development (DSD) are a heterogeneous group of congenital
conditions that result in discordance between an individual's sex chromosomes, gonads …

For several decades now, the analysis of steroids has been a key tool in the diagnosis and
monitoring of numerous endocrine pathologies. Thus, the available methods used to …

Primary aldosteronism (PA) is the most common cause of secondary hypertension and is
associated with increased morbidity and mortality when compared with blood pressure …

Chemical information has become increasingly ubiquitous and has outstripped the pace of
analysis and interpretation. We have developed an R package, uafR, that automates a …

Background Multi-steroid profiling is a powerful analytical tool that simultaneously quantifies
steroids from different biosynthetic pathways. Here we present an ultra-high performance …

Breast cancer is the most common malignancy in women with high mortality. Sensitive and
specific methods for the detection, characterization and quantification of endogenous …

The simultaneous determination of a broad panel of steroids provides more accurate
information about the hormonal status than the detection of a single hormone. For that …