Chemistry and biochemistry of 13 C hyperpolarized magnetic resonance using dynamic nuclear polarization
KR Keshari, DM Wilson - Chemical Society Reviews, 2014 - pubs.rsc.org
The study of transient chemical phenomena by conventional NMR has proved elusive,
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …
Studies of metabolism using 13C MRS of hyperpolarized probes
MM Chaumeil, C Najac, SM Ronen - Methods in enzymology, 2015 - Elsevier
First described in 2003, the dissolution dynamic nuclear polarization (DNP) technique,
combined with 13 C magnetic resonance spectroscopy (MRS), has since been used in …
combined with 13 C magnetic resonance spectroscopy (MRS), has since been used in …
Imaging Metabolism with Hyperpolarized 13C-Labeled Cell Substrates
KM Brindle - Journal of the American Chemical Society, 2015 - ACS Publications
Non-invasive 13C magnetic resonance spectroscopy measurements of the uptake and
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …
Impact of Gd3+ on DNP of [1-13C]Pyruvate Doped with Trityl OX063, BDPA, or 4-Oxo-TEMPO
Hyperpolarized [1-13C] pyruvate has become an important diagnostic tracer of normal and
aberrant cellular metabolism for in vitro and in vivo NMR spectroscopy (MRS) and imaging …
aberrant cellular metabolism for in vitro and in vivo NMR spectroscopy (MRS) and imaging …
Dynamic nuclear polarization in the solid state: a transition between the cross effect and the solid effect
D Shimon, Y Hovav, A Feintuch, D Goldfarb… - Physical Chemistry …, 2012 - pubs.rsc.org
Proton Dynamic Nuclear Polarization (DNP) experiments were conducted on a 3.4 T
homebuilt hybrid pulsed-EPR-NMR spectrometer, on static samples containing 10 mM or 40 …
homebuilt hybrid pulsed-EPR-NMR spectrometer, on static samples containing 10 mM or 40 …
Development of dissolution DNP-MR substrates for metabolic research
Dissolution dynamic nuclear polarization (DNP) provides a broadly applicable and rather
simple means of developing probes for the real-time molecular imaging of cellular functions …
simple means of developing probes for the real-time molecular imaging of cellular functions …
NMR of hyperpolarised probes
C Witte, L Schröder - NMR in Biomedicine, 2013 - Wiley Online Library
Increasing the sensitivity of NMR experiments is an ongoing field of research to help realise
the exquisite molecular specificity of this technique. Hyperpolarisation of various nuclei is a …
the exquisite molecular specificity of this technique. Hyperpolarisation of various nuclei is a …
Dynamic nuclear hyperpolarization in liquids
UL Günther - Modern NMR Methodology, 2013 - Springer
Nuclear magnetic resonance (NMR) spectroscopy is a broadly used analytical method with
major applications in chemistry, biochemistry and medicine. Key applications include …
major applications in chemistry, biochemistry and medicine. Key applications include …
Real‐time cardiac metabolism assessed with hyperpolarized [1‐13C]acetate in a large‐animal model
A Flori, M Liserani, F Frijia, G Giovannetti… - Contrast media & …, 2015 - Wiley Online Library
Dissolution‐dynamic nuclear polarization (dissolution‐DNP) for magnetic resonance (MR)
spectroscopic imaging has recently emerged as a novel technique for noninvasive studies of …
spectroscopic imaging has recently emerged as a novel technique for noninvasive studies of …
Assessing oxidative stress in tumors by measuring the rate of hyperpolarized [1-13C] dehydroascorbic acid reduction using 13C magnetic resonance spectroscopy
KN Timm, DE Hu, M Williams, AJ Wright… - Journal of Biological …, 2017 - ASBMB
Rapid cancer cell proliferation promotes the production of reducing equivalents, which
counteract the effects of relatively high levels of reactive oxygen species. Reactive oxygen …
counteract the effects of relatively high levels of reactive oxygen species. Reactive oxygen …