Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …

Bacterial genomes evolve through mutations, rearrangements or horizontal gene transfer.
Besides the core genes encoding essential metabolic functions, bacterial genomes also …

Horizontal gene transfer is an important mechanism for the evolution of microbial genomes.
Pathogenicity islands—mobile genetic elements that contribute to rapid changes in …

In this review, we focus on a group of mobile genetic elements designated pathogenicity
islands (PAI). These elements play a pivotal role in the virulence of bacterial pathogens of …

The Pseudomonas aeruginosa genome (G+ C content 65–67%, size 5.5–7 Mbp) is made up
of a single circular chromosome and a variable number of plasmids. Sequencing of …

Pseudomonas aeruginosa strains exhibit significant variability in pathogenicity and
ecological flexibility. Such interstrain differences reflect the dynamic nature of the P …

One of the hallmarks of the Gram-negative bacterium Pseudomonas aeruginosa is its ability
to thrive in diverse environments that includes humans with a variety of debilitating diseases …

The opportunistic pathogen Pseudomonas aeruginosa is responsible for systemic infections
in immunocompromised individuals and chronic respiratory disease in patients with cystic …

Integrative and conjugative elements (ICEs) are self-transmissible mobile genetic elements
that are increasingly recognized to contribute to lateral gene flow in prokaryotes. ICEs, like …