Metastasis is the most lethal attribute of a cancer. There is a critical need for markers that will
distinguish accurately those histologic lesions and disseminated cells with a high probability …

Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82
suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In …

A gene from human chromosome 11p11. 2 was isolated and was shown to suppress
metastasis when introduced into rat AT6. 1 prostate cancer cells. Expression of this gene …

Structural characterization of biomolecules in solution by nuclear magnetic resonance
(NMR) spectroscopy is based primarily on the use of interproton distances derived from …

We have used microcell fusion-mediated chromosomal transfer to introduce normal human
chromosomes into highly metastatic rodent prostatic cancer cells to map the location of a …

Metastasis suppressor proteins regulate multiple steps in the metastatic cascade, including
cancer cell invasion, survival in the vascular and lymphatic circulation, and colonization of …

Germline mutations of the putative tumor suppressor gene APC are associated in high
frequency with the familial adenomatous polyposis, predisposing the patients to colorectal …

The CD44 transmembrane glycoprotein of 90 kDa has been known for more than 10 years
under such diverse designations as lymphocyte homing receptor (gp90 Hermes), phagocytic …

The molecular mechanisms and genetic programs required for cancer metastasis are
sometimes overlapping, but components are clearly distinct from those promoting growth of …

The major problem for cancer patients is metastasis of the cancer from the primary tumor to
secondary sites. Metastasis is the process by which tumor cells disseminate from the primary …