Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

Indoles are some of the most versatile and common nitrogen-based heterocyclic scaffolds
and are frequently used in the synthesis of various organic compounds. Indole based …

Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives,
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …

The reaction of one equivalents of 5‐acetylthiadiazole with one equivalent of aldehyde in
acetic acid and ammonium acetate yielded thiadiazolyl‐pyridine derivatives in a …

MAPK pathway sparkles with RTK activation, passes through subsequent downstream RAS-
RAF-MEK-ERK signaling cascades, with consequent direct and indirect CDK4/6 signaling …

The synthesis of a novel series of pyridine and bipyridine derivatives is described via one-
pot multicomponent reaction of 5-acetylimidazole, malonitrile (or ethylcyanoacetate or …

Two series of (nicotinonitrile-thiazole)-based Schiff bases 1 and their bis (Schiff bases)
analogs 2 are efficiently prepared in this study. A one-pot protocol was designed to prepare …

An important bioactive heterocycle having several uses in medicinal chemistry, synthetic
organic chemistry, material chemistry, and natural product is indole along with its analogues …

An efficient, low-cost, high yield% and eco-friendly synthetic procedure is designed for the
synthesis of novel series of nicotinonitrile-coumarin hybrid molecules bearing several aryl …

A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …