18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

S Preshlock, M Tredwell, V Gouverneur - Chemical reviews, 2016 - ACS Publications
Diverse radiochemistry is an essential component of nuclear medicine; this includes
imaging techniques such as positron emission tomography (PET). As such, PET can track …

Microfluidics: a groundbreaking technology for PET tracer production?

C Rensch, A Jackson, S Lindner, R Salvamoser… - Molecules, 2013 - mdpi.com
Application of microfluidics to Positron Emission Tomography (PET) tracer synthesis has
attracted increasing interest within the last decade. The technical advantages of …

Facile aromatic radiofluorination of [18 F] flumazenil from diaryliodonium salts with evaluation of their stability and selectivity

BS Moon, HS Kil, JH Park, JS Kim, J Park… - Organic & …, 2011 - pubs.rsc.org
Aromatic radiofluorination of the diaryliodonium tosylate precursor with [18F] fluoride ions
has been applied successfully to access [18F] flumazenil in high radiochemical yields of …

Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry

A Rios, TS Holloway, PH Chao, C De Caro… - Scientific reports, 2022 - nature.com
The increasing number of positron-emission tomography (PET) tracers being developed to
aid drug development and create new diagnostics has led to an increased need for …

Hypervalent aryliodine compounds as precursors for radiofluorination

VW Pike - Journal of Labelled Compounds and …, 2018 - Wiley Online Library
Over the last 2 decades or so, hypervalent iodine compounds, such as diaryliodonium salts
and aryliodonium ylides, have emerged as useful precursors for labeling homoarenes and …

A rapid and systematic approach for the optimization of radio thin-layer chromatography resolution

TS Laferriere-Holloway, A Rios, Y Lu, CC Okoro… - … of Chromatography A, 2023 - Elsevier
Radiopharmaceutical analysis is limited by conventional methods. Radio-HPLC may be
inaccurate for some compounds (eg, 18 F-radiopharmaceuticals) due to radionuclide …

Imaging in drug development

J Nairne, PB Iveson, A Meijer - Progress in Medicinal Chemistry, 2015 - Elsevier
Imaging has played an important part in the diagnosis of disease and development of the
understanding of the underlying disease mechanisms and is now poised to make an impact …

New radiosynthesis of 2-deoxy-2-[18F] fluoroacetamido-D-glucopyranose and its evaluation as a bacterial infections imaging agent

ME Martínez, Y Kiyono, S Noriki, K Inai… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: The diagnosis of infection and the ability to distinguish bacterial infection
from nonbacterial inflammation by positron emission tomography (PET) have gained interest …

PET radioligands targeting the brain GABAA/benzodiazepine receptor complex

JD Andersson, C Halldin - Journal of Labelled Compounds and …, 2013 - Wiley Online Library
The development of positron emission tomography radioligands for the GABAA/
benzodiazepine receptor complex (GABAA receptor) labeled with 11C and 18F is examined …

Routine Production of [18F]Flumazenil from Iodonium Tosylate Using a Sample Pretreatment Method: a 2.5-Year Production Report

BS Moon, JH Park, HJ Lee, BC Lee, SE Kim - Molecular imaging and …, 2014 - Springer
Abstract Purpose [18 F] Flumazenil, which has the advantage of a longer half-life than [11 C]
flumazenil, is well known for determining of the central benzodiazepine receptor …