To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Tumor microenvironment is considered nowadays as one of the main players in cancer
development and progression. Tumor microenvironment is highly complex and consists of …

Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-
related protein produced in the periosteum and periodontal ligaments. Matricellular proteins …

The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …

The behavior and fate of cells in tissues largely rely upon their cross-talk with the tissue
microenvironment including neighboring cells, the extracellular matrix (ECM), and soluble …

The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing
support and maintaining normal epithelial architecture. In the last decade, increasing …

Gastric cancer is globally the fourth leading cause of cancer-related deaths. Patients with
diffuse-type gastric cancer (DGC) particularly have a poor prognosis that only marginally …

Periostin is a secretory protein with a multi-domain structure, comprising an amino-terminal
cysteine-rich EMI domain, four internal FAS 1 domains, and a carboxyl-terminal hydrophilic …

Substantial progress has been made in using deep learning for cancer detection and
diagnosis in medical images. Yet, there is limited success on prediction of treatment …

Background The tumour stroma microenvironment plays an important part in disease
progression and its composition can influence treatment response and outcomes …