The galectin lattice at a glance

IR Nabi, J Shankar, JW Dennis - Journal of cell science, 2015 - journals.biologists.com
Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The
15 mammalian galectins have either one or two conserved carbohydrate recognition …

Unraveling galectin-1 as a novel therapeutic target for cancer

L Astorgues-Xerri, ME Riveiro… - Cancer treatment …, 2014 - Elsevier
Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-
galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues …

NF-κB and its regulators during pregnancy

F Gómez-Chávez, D Correa… - Frontiers in …, 2021 - frontiersin.org
The transcriptional factor NF-κB is a nuclear factor involved in both physiological and
pathological processes. This factor can control the transcription of more than 400 genes …

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma

DO Croci, M Salatino, N Rubinstein… - Journal of Experimental …, 2012 - rupress.org
Kaposi's sarcoma (KS), a multifocal vascular neoplasm linked to human herpesvirus-8 (HHV-
8/KS-associated herpesvirus [KSHV]) infection, is the most common AIDS-associated …

Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas

I Haecker, LA Gay, Y Yang, J Hu, AM Morse… - 2012 - journals.plos.org
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL),
and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded …

Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease

M Ozen, N Aghaeepour, I Marić, RJ Wong… - Pediatric …, 2023 - nature.com
Immunoperinatology is an emerging field. Transdisciplinary efforts by physicians, physician‐
scientists, basic science researchers, and computational biologists have made substantial …

Clinical relevance of galectin-1 and galectin-3 in rheumatoid arthritis patients: differential regulation and correlation with disease activity

SP Mendez-Huergo, PF Hockl, JC Stupirski… - Frontiers in …, 2019 - frontiersin.org
Galectins, a family of animal lectins, play central roles in immune system regulation, shaping
both innate and adaptive responses in physiological and pathological processes. These …

Galectins: an ancient family of carbohydrate binding proteins with modern functions

H Verkerke, M Dias-Baruffi, RD Cummings… - Galectins: Methods and …, 2022 - Springer
Galectins are a large family of carbohydrate binding proteins with members in nearly every
lineage of multicellular life. Through tandem and en-mass genome duplications, over 15 …

A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis

R Li, M Colombo, G Wang… - Science translational …, 2024 - science.org
Myeloproliferative neoplasms are stem cell–driven cancers associated with a large burden
of morbidity and mortality. Most patients present with early-stage disease, but a substantial …

Galectokines: the promiscuous relationship between galectins and cytokines

L Sanjurjo, EC Broekhuizen, RR Koenen… - Biomolecules, 2022 - mdpi.com
Galectins, a family of glycan-binding proteins, are well-known for their role in shaping the
immune microenvironment. They can directly affect the activity and survival of different …