Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

PARP inhibitors are approved for treating advanced prostate cancers (APC) with various
defective DNA repair genes; however, further studies to clinically qualify predictive …

Mitophagy is an evolutionarily conserved process that selectively targets impaired
mitochondria for degradation. Defects in mitophagy are often associated with diverse …

Mitochondria are essential highly dynamic organelles that provide the necessary energy for
a variety of different processes, such as survival, proliferation, and migration. In order to …

Despite advances in cancer treatment, immune checkpoint blockade (ICB) only achieves
complete response in some patients, illustrating the need to identify resistance mechanisms …

Cancer expression of PD-L1 suppresses anti-tumor immunity. PD-L1 has emerged as a
remarkable therapeutic target. However, the regulation of PD-L1 degradation is not …

E3 ubiquitin protein ligase encoded by ARIH2 gene catalyses the ubiquitination of target
proteins and plays a crucial role in posttranslational modifications across various cellular …

MicroRNAs (miRNAs) play critical roles in a broad variety of biological processes by
inhibiting translation initiation and by destabilizing target mRNAs. The CCR4–NOT complex …

Abstract RING-in-between-RING (RBR) E3 ligases are one class of E3 ligases that is
characterized by the unique RING-HECT hybrid mechanism to function with E2s to transfer …