First marketed as RoundUp, glyphosate is history's most popular herbicide because of its
low acute toxicity to metazoans and broad-spectrum effectiveness across plant species. The …

The main purpose of this paper was to generate a narrative review related to the current
knowledge of the TP53 gene and its product, the p53 protein. It was also attempted to …

In recent years, chronic degenerative diseases such as certain types of cancers, are
becoming an evident issue. DNA damage has been for long recognized as a causal factor …

In vitro evolution and whole genome analysis were used to comprehensively identify the
genetic determinants of chemical resistance in Saccharomyces cerevisiae. Sequence …

Improving the resistance of Saccharomyces cerevisiae to vanillin, derived from lignin, will
benefit the design of robust cell factories for lignocellulosic biorefining. The transcription …

Copper (Cu) was used in antiquity to prevent waterborne and food diseases because, as a
broad-spectrum antimicrobial agent, it generates reactive oxygen species, ROS. New …

Caffeine is a natural compound that inhibits the major cellular signaling regulator target of
rapamycin (TOR), leading to widespread effects including growth inhibition. Saccharomyces …

S. cerevisiae from different environments are subject to a wide range of selective pressures,
whether intentional or by happenstance. Chemicals classified by their application, such as …

The Mediator is composed of multiple subunits conserved from yeast to humans and plays a
central role in transcription. The tail components are not required for basal transcription but …

Cellular metabolism can change the potency of a chemical's tumorigenicity. 4-nitroquinoline-
1-oxide (4NQO) is a tumorigenic drug widely used on animal models for cancer research …