Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome

E Fraison, E Kostova, LJ Moran, S Bilal… - Cochrane Database …, 2020 - cochranelibrary.com
Background Metformin has been proposed as possibly a safer and more effective long‐term
treatment than the oral contraceptive pill (OCP) in women with polycystic ovary syndrome …

Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women

L Ibáñez, F de Zegher - Human reproduction update, 2006 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a variable disorder that is characterized in adolescents
and young women by a broad spectrum of anomalies, including hyperandrogenemia, insulin …

Serum levels of TSP‐1, NF‐κB and TGF‐β1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation

M Liu, J Gao, Y Zhang, P Li, H Wang… - Clinical …, 2015 - Wiley Online Library
Objective The objective of this study was to determine the levels of thrombospondin‐1 (TSP‐
1), transforming growth factor‐β1 (TGF‐β1) and nuclear factor kappaβ (NF‐κβ) in polycystic …

Combined oral contraceptives and/or antiandrogens versus insulin sensitizers for polycystic ovary syndrome: a systematic review and meta-analysis

M Luque-Ramirez, L Nattero-Chavez… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Androgen excess is a key pathogenetic mechanism in polycystic ovary
syndrome (PCOS), although hyperinsulinism also contributes to androgen secretion …

Hyperinsulinaemic androgen excess in adolescent girls

L Ibanez, KK Ong, A Lopez-Bermejo… - Nature reviews …, 2014 - nature.com
Hyperinsulinaemic androgen excess is the most common cause of hirsutism, acne and
menstrual irregularity in adolescent girls. Here, we propose that the disorder frequently …

State of the art review: emerging therapies: the use of insulin sensitizers in the treatment of adolescents with polycystic ovary syndrome (PCOS)

DH Geller, D Pacaud, CM Gordon, M Misra… - International Journal of …, 2011 - Springer
PCOS, a heterogeneous disorder characterized by cystic ovarian morphology, androgen
excess, and/or irregular periods, emerges during or shortly after puberty. Peri-and post …

Metformin beyond diabetes: new life for an old drug

CM Rotella, M Monami… - Current diabetes reviews, 2006 - ingentaconnect.com
Metformin is a widely used drug in the therapy of patients affected by diabetes mellitus.
Although some caution is needed in the very old, advanced age per se does not represent a …

The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review

Z Jing, X Liang-Zhi, W Tai-Xiang, T Ying… - Gynecological …, 2008 - Taylor & Francis
Objectives. To systematically evaluate the efficacy and safety of Diane-35 for treating
polycystic ovary syndrome (PCOS) and compare it with metformin, either in combination or …

Clinical and metabolic effects of medroxyprogesterone acetate and ethinyl estradiol plus drospirenone in women with polycystic ovary syndrome

S Özdemir, H Görkemli, K Gezginç, M Özdemir… - International Journal of …, 2008 - Elsevier
Objectives: To investigate the effects of treatment with medroxyprogesterone acetate (MPA),
10 days per month for 6 months, on lipid and carbohydrate metabolism in women with …

Comparison of four different treatment regimens on coagulation parameters, hormonal and metabolic changes in women with polycystic ovary syndrome

L Kebapcilar, CE Taner, AG Kebapcilar… - Archives of gynecology …, 2010 - Springer
Objective To determine the effects of different treatment regimens on the hormonal features,
metabolic parameters, and hematologic variables in women with polycystic ovary syndrome …