Various AAV serotypes and their applications in gene therapy: an overview

SS Issa, AA Shaimardanova, VV Solovyeva… - Cells, 2023 - mdpi.com
Despite scientific discoveries in the field of gene and cell therapy, some diseases still have
no effective treatment. Advances in genetic engineering methods have enabled the …

Role of thymus in health and disease

S Gulla, MC Reddy, VC Reddy, S Chitta… - International Reviews …, 2023 - Taylor & Francis
The thymus is a primary lymphoid organ, essential for the development of T-cells that will
protect from invading pathogens, immune disorders, and cancer. The thymus decreases in …

Anti-CD45RC antibody immunotherapy prevents and treats experimental autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy syndrome

M Besnard, C Sérazin, J Ossart… - The Journal of …, 2022 - Am Soc Clin Investig
Targeted monoclonal antibody (mAb) therapies show great promise for the treatment of
transplant rejection and autoimmune diseases by inducing more specific immunomodulatory …

Identification of AIRE pathogenic variants ends diagnostic odyssey for Saudi child with infantile-onset keratoconjunctivitis as an early sign of autoimmune …

M Alkhalifah, H AlMezaine, B AlMoallem - Ophthalmic Genetics, 2024 - Taylor & Francis
Purpose Chronic keratoconjunctivitis is a rare presentation of autoimmune polyglandular
syndrome type 1 (APS-1) during the first year of life. Herein, We report a case of a 10-month …

Characterisation of APS‐1 Experimental Models Is Crucial for Development of Novel Therapies

S Almaghrabi, T Lovewell, M Azzouz… - BioMed Research …, 2023 - Wiley Online Library
Autoimmune polyglandular syndrome type 1 (APS‐1) is an inherited autosomal disorder.
The most common clinical features of the disease include adrenocortical failure …

[PDF][PDF] Role of autoimmune regulator (AIRE) in the pathogenesis of neurological disorders associated with autoimmune polyglandular syndrome type 1

F Albalawi - 2022 - etheses.whiterose.ac.uk
Autoimmune polyglandular syndrome type 1 (APS-1) or autoimmune polyendocrinopathy-
candidiasis–ectodermal dystrophy/dysplasia (APECED) is a monogenic autosomal …