Nanoscale objects are processed by living organisms using highly evolved and
sophisticated endogenous cellular networks, specifically designed to manage objects of this …

Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

First evidence of geometrical patterns and defined distances of biomolecules as
fundamental parameters to regulate receptor binding and cell signaling have emerged …

What counts as an individual in the living world? What does it mean for a living thing to
remain the same through time, while constantly changing? These questions are the province …

The trafficking of leukocytes into and within lymphoid and peripheral tissues is central to
immune cell development, immunosurveillance and effector function. Interstitial leukocyte …

The interaction of T cells with dendritic cells (DCs) determines whether an immune response
is launched or not. Recognition of antigen leads to formation of immunological synapses at …

This paper presents a critical review of selected topics related to the modelling of cancer
onset, evolution and growth, with the aim of illustrating, to a wide applied mathematical …

Accumulating data are documenting an inverse relationship between immune status,
response to vaccination, health, and longevity, suggesting that the immune system becomes …

T helper (Th) cell activation is required for the adaptive immune response. Formation of the
immunological synapse (IS) between Th cells and antigen-presenting cells is essential for …

Artificial antigen-presenting cells (aAPCs) can stimulate CD8+ T cell activation. While
nanosized aAPCs (naAPCs) have a better safety profile than microsized (maAPCs), they …