Design, synthesis of antipyrine-based Schiff bases and investigation of their cholinesterase and carbonic anhydrase activities by in vitro and in silico approaches
In this study, a series of antipyrine-based Schiff bases (1–10) was designed, synthesized,
and evaluated as potential inhibitors of various metabolic enzymes, including …
and evaluated as potential inhibitors of various metabolic enzymes, including …
Synthesis of new sulfonamide derivatives: Investigation of their interactions with carbonic anhydrase and cholinesterase enzymes by in vitro and in silico evaluations
In this study, a series of novel sulfonamide derivatives (6-10) bearing an aryl sulfonate
moiety was designed, and synthesized for the first time, and their inhibitory activities against …
moiety was designed, and synthesized for the first time, and their inhibitory activities against …
[HTML][HTML] Identification of coumarin derivatives targeting acetylcholinesterase for Alzheimer's disease by field-based 3D-QSAR, pharmacophore model-based virtual …
Alzheimer's disease (AD) leads to gradual memory loss including other compromised
cognitive abilities. Acetylcholinesterase (AChE), an important biochemical enzyme from the …
cognitive abilities. Acetylcholinesterase (AChE), an important biochemical enzyme from the …
New Sulfonate Ester‐Linked Fluorinated Hydrazone Derivatives as Multitarget Carbonic Anhydrase and Cholinesterase Inhibitors: Design, Synthesis, Biological …
In this study, some new hydrazone derivatives (2a–g) was designed, synthesized for first
time, and evaluated as multitarget inhibitors of AChE, BChE, hCA I and hCA II. The chemical …
time, and evaluated as multitarget inhibitors of AChE, BChE, hCA I and hCA II. The chemical …
Discovery of a Uracil‐Derived Small Organic Ligand with Cytotoxic Effect on Human PC‐3 Cell Lines via Apoptosis
A series of novel 6‐amino‐5‐salicylidene uracils (1–19) were efficiently synthesized from
the condensation reaction of 5, 6‐diamino‐1, 3‐dimethyluracil with substituted …
the condensation reaction of 5, 6‐diamino‐1, 3‐dimethyluracil with substituted …