Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment‐related aspects of apathy from depression in …

KL Lanctôt, Z Ismail, KK Bawa… - … journal of geriatric …, 2023 - Wiley Online Library
Objectives This narrative review describes the clinical features of apathy and depression in
individuals with neurocognitive disorders (NCDs), with the goal of differentiating the two …

Amidst an amygdala renaissance in Alzheimer's disease

KM Stouffer, X Grande, E Duezel, M Johansson… - Brain, 2024 - academic.oup.com
The amygdala was highlighted as an early site for neurofibrillary tau tangle pathology in
Alzheimer's disease in the seminal 1991 article by Braak and Braak. This knowledge has …

Progression to dementia or reversion to normal cognition in mild cognitive impairment as a function of late-onset neuropsychiatric symptoms

A McGirr, S Nathan, M Ghahremani, S Gill, EE Smith… - Neurology, 2022 - AAN Enterprises
Background and Objectives Mild cognitive impairment (MCI) is an at-risk state for dementia;
however, not all individuals with MCI transition to dementia, and some revert to normal …

Validating the mild behavioral impairment checklist in a cognitive clinic: comparisons with the neuropsychiatric inventory questionnaire

S Hu, S Patten, A Charlton, K Fischer… - Journal of geriatric …, 2023 - journals.sagepub.com
Objective To compare the utility of the Mild Behavioral Impairment-Checklist (MBI-C) and
Neuropsychiatric Inventory Questionnaire (NPI-Q) to capture NPS in subjective cognitive …

Optimizing detection of Alzheimer's disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO

Z Ismail, R Leon, B Creese, C Ballard, P Robert… - Molecular …, 2023 - Springer
Background Disease-modifying drug use necessitates better Alzheimer disease (AD)
detection. Mild cognitive impairment (MCI) leverages cognitive decline to identify the risk …

Plasma β-amyloid in mild behavioural impairment–neuropsychiatric symptoms on the Alzheimer's continuum

R Miao, HY Chen, S Gill, J Naude… - Journal of geriatric …, 2022 - journals.sagepub.com
Introduction: Simple markers are required to recognize older adults at higher risk for
neurodegenerative disease. Mild behavioural impairment (MBI) and plasma β-amyloid (Aβ) …

Plasma phosphorylated tau at threonine 181 and neuropsychiatric symptoms in preclinical and prodromal Alzheimer disease

M Ghahremani, M Wang, HY Chen, H Zetterberg… - Neurology, 2023 - AAN Enterprises
Background and Objectives Plasma phosphorylated tau at threonine 181 (p-tau181), a well-
validated marker of Alzheimer disease (AD) pathologic change, could be a more efficient …

Cognitive profile of people with mild behavioral impairment in Brain Health Registry participants

F Kassam, H Chen, RL Nosheny, A McGirr… - International …, 2023 - cambridge.org
Objectives: Dementia assessment includes cognitive and behavioral testing with informant
verification. Conventional testing is resource-intensive, with uneven access. Online …

Functional connectivity and mild behavioral impairment in dementia‐free elderly

M Ghahremani, S Nathan, EE Smith… - … Research & Clinical …, 2023 - Wiley Online Library
Background Mild behavioral impairment (MBI) is a syndrome that uses later‐life emergent
and persistent neuropsychiatric symptoms (NPS) to identify a group at high risk for incident …

Mild behavioral impairment is associated with progression to Alzheimer's disease: a clinicopathological study

M Ruthirakuhan, Z Ismail, N Herrmann… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Mild behavioral impairment (MBI) is characterized by later‐life emergence of
neuropsychiatric symptoms. Investigating its relationship with progression to Alzheimer's …