Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …

Tissue-resident innate immune cells have important functions in both homeostasis and
pathological states. Despite advances in the field, analyzing the metabolism of tissue …

Coordination of cellular metabolism is essential for optimal T cell responses. Here, we
identify cytosolic acetyl-CoA production as an essential metabolic node for CD8 T cell …

Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses.
As lipids impact cell signaling and function, we compare the lipid composition of CD4+ …

Tumors are inherently embedded in systemic physiology, which contributes metabolites,
signaling molecules, and immune cells to the tumor microenvironment. As a result, any …

A simple definition of life is a system that can self-replicate (proliferation) and self-sustain
(metabolism). At the cellular level, metabolism has evolved to drive proliferation, which …

Metabolic competition between tumor cells and killer T cells induces microenvironmental
nutrient deficiencies and an immunosuppressive tumor microenvironment (TME), leading to …

GOT1, a cytoplasmic glutamic oxaloacetic transaminase, plays a critical role in various
metabolic pathways essential for cellular homeostasis and dysregulated metabolism …

Metabolomics is a bottom-up approach to studying metabolism in living cells, tissues,
organoids, or even whole organisms. In conjunction with genomics and proteomics, it is a …

For over a century, we have appreciated that the biochemical processes through which
micro-and macronutrients are anabolized and catabolized—collectively referred to as …