A membrane protein required for dislocation of misfolded proteins from the ER
After insertion into the endoplasmic reticulum (ER), proteins that fail to fold there are
destroyed. Through a process termed dislocation such misfolded proteins arrive in the …
destroyed. Through a process termed dislocation such misfolded proteins arrive in the …
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane
Polypeptides that fail to pass quality control in the endoplasmic reticulum (ER) are
dislocated from the ER membrane to the cytosol where they are degraded by the …
dislocated from the ER membrane to the cytosol where they are degraded by the …
The hepatic transcriptome in human liver disease
The transcriptome is the mRNA transcript pool in a cell, organ or tissue with the liver
transcriptome being amongst the most complex of any organ. Functional genomics …
transcriptome being amongst the most complex of any organ. Functional genomics …
Reversible Kinetic Analysis of Myc Targets In vivo Provides Novel Insights into Myc-Mediated Tumorigenesis
ER Lawlor, L Soucek, L Brown-Swigart, K Shchors… - Cancer research, 2006 - AACR
Deregulated expression of the Myc transcription factor is a frequent causal mutation in
human cancer. Thousands of putative Myc target genes have been identified in in vitro …
human cancer. Thousands of putative Myc target genes have been identified in in vitro …
LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma
J Yan, Y Yu, N Wang, Y Chang, H Ying, W Liu, J He… - Oncogene, 2004 - nature.com
We have previously identified several novel genes, which are differentially expressed
among human normal liver and hepatocellular carcinomas (HCCs). The full-length liver …
among human normal liver and hepatocellular carcinomas (HCCs). The full-length liver …
Differential expression profiling of head and neck squamous cell carcinoma (HNSCC)
F Lemaire, R Millon, J Young, A Cromer… - British journal of …, 2003 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in men
with an incidence of about 780 000 new cases per year worldwide and a poor rate of …
with an incidence of about 780 000 new cases per year worldwide and a poor rate of …
Cloning and characterization of a mouse liver-specific gene mfrep-1, upregulated in liver regeneration
J Yan, H Ying, F Gu, J He, YL Li, HM Liu, YH Xu - Cell research, 2002 - nature.com
ABSTRACT Human fibrinogen-related protein-1/liver fibrinogen-related protein-1 (HFREP-
1/LFIRE-1), a liver-specific protein, is a member of fibrinogen superfamily that exerts various …
1/LFIRE-1), a liver-specific protein, is a member of fibrinogen superfamily that exerts various …
[HTML][HTML] Tributyrin inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest
J Yan, YH Xu - World Journal of Gastroenterology: WJG, 2003 - ncbi.nlm.nih.gov
AIM: To evaluate the effects of tributyrin, a pro-drug of natural butyrate and a neutral short-
chain fatty acid triglyceride, on the growth inhibition of human gastric cancer SGC-7901 cell …
chain fatty acid triglyceride, on the growth inhibition of human gastric cancer SGC-7901 cell …
Multi-omics data integration approaches to study glucocorticoid receptor function
K Balázs - 2021 - mediatum.ub.tum.de
In this thesis I undertook a multi-omics data integration approach to study transcriptional
regulation of hepatic metabolism by the glucocorticoid receptor in mice. We performed …
regulation of hepatic metabolism by the glucocorticoid receptor in mice. We performed …