Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

Reactive oxygen species (ROS), such as the superoxide anion or hydrogen peroxide, have
been established over decades of research as, on the one hand, important and versatile …

T cells undergo metabolic reprogramming and multiple biological processes to satisfy their
energetic and biosynthetic demands throughout their lifespan. Several of these metabolic …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Reactive species are highly-reactive enzymatically, or non-enzymatically produced
compounds with important roles in physiological and pathophysiological cellular processes …

Oxidative stress is a condition determined by an imbalance between antioxidant and
oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed …

Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital entry
points for monosaccharides and amino acids into the Krebs cycle and thus integral for …

Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases
exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and …

With advances in immunometabolic studies, more and more evidence has shown that
metabolic changes profoundly affect the immune function of macrophages. The tricarboxylic …