This article provides a synopsis of current progress made in fundamental studies of lower
urinary tract dysfunction (LUTD) after spinal cord injury (SCI) above the sacral level. Animal …

CONTEXT: The focus of clinical understanding and management of male storage lower
urinary tract symptoms (LUTS) has shifted from the prostate to the bladder. This is mirrored …

Treating pain by inhibiting ATP activation of P2X3-containing receptors heralds an exciting
new approach to pain management, and Afferent's program marks the vanguard in a new …

The purpose of this paper was to simultaneously examine changes in urothelial ATP and NO
release in normal and spinal cord injured animals as well as in spinal cord injured animals …

Acetylcholine acting on muscarinic M3 receptors on the detrusor muscle is the principal
stimulus for inducing the contractile response for urinary bladder voiding. The urinary …

Beyond serving as a simple barrier, there is growing evidence that the urinary bladder
urothelium exhibits specialized sensory properties and play a key role in the detection and …

Antimuscarinic drugs affect bladder sensory symptoms such as urgency and frequency,
presumably by acting on muscarinic acetylcholine receptors (mAChRs) located in bladder …

Abstract P2X and P2Y nucleotide receptors are described on sensory neurons and their
peripheral and central terminals in dorsal root, nodose, trigeminal, petrosal, retinal and …

Transient receptor potential (TRP) and acid-sensing ion channels (ASIC) are molecular
detectors of chemical, mechanical, thermal, and nociceptive stimuli in sensory neurons …

The pharmacological concept of specifically targeting purinoceptors (receptors for ATP and
related nucleotides) has emerged over the last two decades in the quest for novel …