Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Although the role of ferroptosis in killing tumor cells is well established, recent studies
indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils …

Mutations in the p53 gene compromise its role as guardian of genomic integrity, yielding
predominantly missense p53 mutant proteins. The gain-of-function hypothesis has long …

Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid
peroxidation. A model cell system is constructed to induce ferroptosis by re-expressing the …

Cell death resistance represents a hallmark of cancer. Recent studies have identified
metabolic cell death as unique forms of regulated cell death resulting from an imbalance in …

Ferroptosis is a type of regulated cell death characterized by iron accumulation and
uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular …

The TP53 tumor suppressor gene is mutated early in most of the patients with triple-negative
breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that …

Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Summary p53 was discovered 45 years ago as an SV40 large T antigen binding protein,
coded by the most frequently mutated TP53 gene in human cancers. As a transcription …