Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …

The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …

The bile acid–responsive G protein–coupled receptor TGR5 is involved in several metabolic
processes, and recent studies suggest that TGR5 activation may promote pathways that are …

The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and
premalignant cancer cells, the TGFβ signaling pathway inhibits proliferation and promotes …

During breast cancer progression, transforming growth factor-beta (TGF-β) switches from
acting as a growth inhibitor to become a major promoter of epithelial-mesenchymal …

Monocyte/macrophages play an important role in orchestrating the immune response. The
present review refers to C/EBPβ, which is a key transcription factor regulating monocytic …

TGFβ signaling inhibits cell proliferation to block cancer initiation, yet it also enhances
metastasis to promote malignancy during breast cancer development. The mechanisms …

Background: There are currently no biomarkers for early breast cancer patient populations at
risk of bone metastasis. Identification of mediators of bone metastasis could be of clinical …

The transcription factor C/EBPβ is a master regulator of mammary gland development and
tissue remodelling during lactation. The CEBPB-mRNA is translated into three distinct …

The c-MYC (MYC) oncoprotein is often overexpressed in human breast cancer; however, its
role in driving disease phenotypes is poorly understood. Here, we investigate the role of …