Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury
Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …
COVID-19, pre-eclampsia, and complement system
C Agostinis, A Mangogna, A Balduit… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together
with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with …
with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with …
[HTML][HTML] Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker
To define cellular mechanisms underlying kidney function and failure, the KPMP analyzes
biopsy tissue in a multicenter research network to build cell-level process maps of the …
biopsy tissue in a multicenter research network to build cell-level process maps of the …
Assessment of network module identification across complex diseases
Many bioinformatics methods have been proposed for reducing the complexity of large gene
or protein networks into relevant subnetworks or modules. Yet, how such methods compare …
or protein networks into relevant subnetworks or modules. Yet, how such methods compare …
Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo
Activated protein C (APC) is a multifunctional serine protease with anticoagulant,
cytoprotective, and anti-inflammatory activities. In addition to the cytoprotective effects of …
cytoprotective, and anti-inflammatory activities. In addition to the cytoprotective effects of …
Impact of fibrinogen, fibrin thrombi, and thrombin on cancer cell extravasation using in vitro microvascular networks
A bidirectional association exists between metastatic dissemination and the
hypercoagulable state associated with many types of cancer. As such, clinical studies have …
hypercoagulable state associated with many types of cancer. As such, clinical studies have …
Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock
J Helms, H Merdji, S Loewert, F Severac… - Annals of Intensive …, 2023 - Springer
Background Disseminated intravascular coagulation (DIC) worsens the prognosis of septic
shock and contributes to multiple organ failure. To date, no data linking DIC and acute …
shock and contributes to multiple organ failure. To date, no data linking DIC and acute …
MicroRNAs and their delivery in diabetic fibrosis
A Wonnacott, L Denby, RJM Coward, DJ Fraser… - Advanced drug delivery …, 2022 - Elsevier
The global prevalence of diabetes mellitus was estimated to be 463 million people in 2019
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …
Protease-activated receptors in kidney diseases: A comprehensive review of pathological roles, therapeutic outcomes and challenges
Studies have demonstrated that protease-activated receptors (PARs) with four subtypes
(PAR1-4) are mainly expressed in the renal epithelial, endothelial, and podocyte cells …
(PAR1-4) are mainly expressed in the renal epithelial, endothelial, and podocyte cells …
Hirudin protects against kidney damage in streptozotocin-induced diabetic nephropathy rats by inhibiting inflammation via P38 MAPK/NF-κB pathway
J Han, X Pang, Y Zhang, Z Peng, X Shi… - Drug Design …, 2020 - Taylor & Francis
Background Inflammation-induced podocyte apoptosis plays an important role in kidney
injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from …
injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from …