Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Neuronal migration is, along with axon guidance, one of the fundamental mechanisms
underlying the wiring of the brain. As other organs, the nervous system has acquired the …

The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …

Reelin is a glycoprotein that serves important roles both during development (regulation of
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …

Neuronal migration is critical for establishing neocortical cell layers and migration defects
can cause neurological and psychiatric diseases. Recent studies show that radially …

Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk
factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have …

Abstract Disrupted-In-Schizophrenia-1 (DISC1), originally identified at the breakpoint of a
chromosomal translocation that is linked to a rare familial schizophrenia, has been …

Reelin, a multifunctional extracellular protein that is important for mammalian brain
development and function, is secreted by different cell types in the prenatal or postnatal …