Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

FM Kashkooli, M Soltani, M Souri - Journal of controlled release, 2020 - Elsevier
Advances in nanomedicine, including early cancer detection, targeted drug delivery, and
personalized approaches to cancer treatment are on the rise. For example, targeted drug …

Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

M Souri, M Soltani, FM Kashkooli… - Journal of Controlled …, 2022 - Elsevier
Nanocarriers have been widely employed in preclinical studies and clinical trials for the
delivery of anticancer drugs. The most important causes of failure in clinical translation of …

[HTML][HTML] Towards principled design of cancer nanomedicine to accelerate clinical translation

M Souri, M Soltani, FM Kashkooli, MK Shahvandi… - Materials Today Bio, 2022 - Elsevier
Nanotechnology in medical applications, especially in oncology as drug delivery systems,
has recently shown promising results. However, although these advances have been …

Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

FM Kashkooli, M Soltani, M Souri, C Meaney… - Nano Today, 2021 - Elsevier
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …

The facial motor system

L Cattaneo, G Pavesi - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Facial movements support a variety of functions in human behavior. They participate in
automatic somatic and visceral motor programs, they are essential in producing …

Modified bovine milk exosomes for doxorubicin delivery to triple-negative breast cancer cells

J Pullan, K Dailey, S Bhallamudi, L Feng… - ACS applied bio …, 2022 - ACS Publications
Biological nanoparticles, such as exosomes, offer an approach to drug delivery because of
their innate ability to transport biomolecules. Exosomes are derived from cells and an …

Interstitial fluid flow in cancer: implications for disease progression and treatment

JM Munson, AC Shieh - Cancer management and research, 2014 - Taylor & Francis
As cancer progresses, a dynamic microenvironment develops that creates and responds to
cellular and biophysical cues. Increased intratumoral pressure and corresponding increases …

A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors

F Moradi Kashkooli, M Souri, J Tavakkoli… - Drug Delivery, 2023 - Taylor & Francis
Focused Ultrasound (FUS)-triggered nano-sized drug delivery, as a smart stimuli-responsive
system for treating solid tumors, is computationally investigated to enhance localized …

[HTML][HTML] Numerical modeling of drug delivery in a dynamic solid tumor microvasculature

M Sefidgar, M Soltani, K Raahemifar, M Sadeghi… - Microvascular …, 2015 - Elsevier
The complicated capillary network induced by angiogenesis is one of the main reasons of
unsuccessful cancer therapy. A multi-scale mathematical method which simulates drug …

Convection-enhanced delivery: connection to and impact of interstitial fluid flow

CA Stine, JM Munson - Frontiers in oncology, 2019 - frontiersin.org
Convection-enhanced delivery (CED) is a method used to increase transport of therapeutics
in and around brain tumors. CED works through locally applying a pressure differential to …