The eosinophilic leukocyte: structure and function

GJ Gleich, CR Adolphson - Advances in immunology, 1986 - Elsevier
Publisher Summary This chapter reviews information on eosinophil structure and function
and provide evidence for the eosinophil as an effector cell for killing helrninths and for …

Leukocytic oxygen activation and microbicidal oxidative toxin

JK Hurst, WC Barrette - Critical Reviews in Biochemistry and …, 1989 - Taylor & Francis
This review is concerned with the oxidative chemistry of phagocytes (Gk. phagos=
devouring, kytos= container), the motile cells in animals that constitute the primary cellular …

Brominating oxidants generated by human eosinophils

SJ Weiss, ST Test, CM Eckmann, D Roos, S Regiani - Science, 1986 - science.org
Eosinophils are white blood cells that in humans are found in association with helminthic
infections and various inflammatory disease processes. These cells contain a unique …

Eosinophil peroxidase nitrates protein tyrosyl residues: implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders

W Wu, Y Chen, SL Hazen - Journal of Biological Chemistry, 1999 - ASBMB
Eosinophil peroxidase (EPO) has been implicated in promoting oxidative tissue injury in
conditions ranging from asthma and other allergic inflammatory disorders to cancer and …

Raman microspectroscopic approach to the study of human granulocytes

GJ Puppels, HS Garritsen, GM Segers-Nolten… - Biophysical journal, 1991 - cell.com
A sensitive confocal Raman microspectrometer was employed to record spectra of nuclei
and cytoplasmic regions of single living human granulocytes. Conditions were used that …

Eosinophil peroxidase oxidation of thiocyanate: characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system

M Arlandson, T Decker, VA Roongta, L Bonilla… - Journal of Biological …, 2001 - ASBMB
Although the pseudohalide thiocyanate (SCN−) is the preferred substrate for eosinophil
peroxidase (EPO) in fluids of physiologic halide composition, the product (s) of this reaction …

Eosinophils and neutrophils—molecular differences revealed by spontaneous Raman, CARS and fluorescence microscopy

A Dorosz, M Grosicki, J Dybas, E Matuszyk… - Cells, 2020 - mdpi.com
Leukocytes are a part of the immune system that plays an important role in the host's
defense against viral, bacterial, and fungal infections. Among the human leukocytes, two …

Biochemical Evidence for Heme Linkage through Esters with Asp-93 and Glu-241 in Human Eosinophil Peroxidase: The ester with Asp-93 is only partially formed in …

C Oxvig, AR Thomsen, MT Overgaard… - Journal of Biological …, 1999 - ASBMB
The covalent heme attachment has been extensively studied by spectroscopic methods in
myeloperoxidase and lactoperoxidase (LPO) but not in eosinophil peroxidase (EPO). We …

Intracellular reactions in single human granulocytes upon phorbol myristate acetate activation using confocal Raman microspectroscopy

NM Sijtsema, AGJ Tibbe, IGMJ Segers-Nolten… - Biophysical journal, 2000 - cell.com
We have obtained new evidence for the occurrence of intracellular NADPH-oxidase activity
in neutrophilic and eosinophilic granulocytes upon stimulation with phorbol myristate …

Resonance Raman microspectroscopic characterization of eosinophil peroxidase in human eosinophilic granulocytes

BL Salmaso, GJ Puppels, PJ Caspers, R Floris… - Biophysical journal, 1994 - cell.com
A resonance Raman microspectroscopic study is presented of eosinophil peroxidase (EPO)
in human eosinophilic granulocytes. Experiments were carried out at the single cell level …