The global contamination of water resources by organic contaminants such as
pharmaceuticals and pesticides is calling for advanced remediation techniques, yet …

Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a
highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly …

The Wacker reaction is the oxidation of olefins to ketones and typically requires expensive
and scarce palladium catalysts in the presence of an additional copper co‐catalyst under …

Ketones are crucial intermediates in synthesis and frequent moieties in many products. The
direct regioselective synthesis of ketones from internal alkenes could simplify synthetic …

Nature has devised intrinsic electric fields (IEFs) that are engaged in electrostatic catalysis of
enzymes. But, how does the IEF target its function in enzymes that involve several reaction …

Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses a long-
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …

New-to-nature radical biocatalysis has recently emerged as a powerful strategy to tame
fleeting open-shell intermediates for stereoselective transformations. In 2021, we introduced …

Terpene cyclization, one of the most complex chemical reactions in nature, is generally
catalyzed by two classes of terpene cyclases (TCs). Cytochrome P450s that act as …

Despite their intriguing photophysical and photochemical activities, naturally occurring
photoenzymes have not yet been repurposed for new-to-nature activities. Here we …

Uranyl cation, as an emerging photocatalyst, has been successfully applied to synthetic
chemistry in recent years and displayed remarkable catalytic ability under visible light …