Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

Missense mutations in the C-terminal B30. 2 domain of pyrin cause familial Mediterranean
fever (FMF), the most common Mendelian autoinflammatory disease. However, it remains …

Summary While interleukin (IL)-1β plays an important role in combating the invading
pathogen as part of the innate immune response, its dysregulation is responsible for a …

Background The present review is part of the ESCMID Study Group for Infections in
Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and …

The inflammatory cytokines IL-1α and IL-1β orchestrate local and systemic inflammatory
responses underlying a broad spectrum of diseases. Three agents for reducing IL-1 …

Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of
fever, pain and inflammation, is at present experiencing a revival in biology and medicine …

Chinese translation This article has been corrected. The original version (PDF) is appended
to this article as a Supplement. Background: Currently, there is no proven alternative therapy …

OBJECTIVES: Familial Mediterranean fever (FMF) is an autosomal-recessive
autoinflammatory disorder common in Mediterranean populations. FMF is associated with …