TLX, an orphan nuclear receptor with emerging roles in physiology and disease
Abstract TLX (NR2E1), an orphan member of the nuclear receptor superfamily, is a
transcription factor that has been described to be generally repressive in nature. It has been …
transcription factor that has been described to be generally repressive in nature. It has been …
The orphan nuclear receptor TLX/NR2E1 in neural stem cells and diseases
T Wang, JQ Xiong - Neuroscience bulletin, 2016 - Springer
The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the
central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse …
central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse …
Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells
AJ Korecki, JL Cueva-Vargas, O Fornes, J Agostinone… - Gene Therapy, 2021 - nature.com
Small and cell-type restricted promoters are important tools for basic and preclinical
research, and clinical delivery of gene therapies. In clinical gene therapy, ophthalmic trials …
research, and clinical delivery of gene therapies. In clinical gene therapy, ophthalmic trials …
Twenty-seven tamoxifen-inducible iCre-driver mouse strains for eye and brain, including seventeen carrying a new inducible-first constitutive-ready allele
AJ Korecki, JW Hickmott, SL Lam, L Dreolini… - Genetics, 2019 - academic.oup.com
To understand gene function, the cre/loxP conditional system is the most powerful available
for temporal and spatial control of expression in mouse. However, the research community …
for temporal and spatial control of expression in mouse. However, the research community …
Co-activator candidate interactions for orphan nuclear receptor NR2E1
X Corso-Díaz, CN de Leeuw, V Alonso, D Melchers… - BMC genomics, 2016 - Springer
Abstract Background NR2E1 (Tlx) is an orphan nuclear receptor that regulates the
maintenance and self-renewal of neural stem cells, and promotes tumourigenesis. Nr2e1 …
maintenance and self-renewal of neural stem cells, and promotes tumourigenesis. Nr2e1 …
[HTML][HTML] Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage
Familial dysautonomia (FD), a hereditary sensory and autonomic neuropathy, is caused by a
mutation in the Elongator complex protein 1 (ELP1) gene that leads to a tissue-specific …
mutation in the Elongator complex protein 1 (ELP1) gene that leads to a tissue-specific …
Nr2e1 regulates retinal lamination and the development of Müller glia, S-cones, and glycineric amacrine cells during retinogenesis
X Corso-Díaz, EM Simpson - Molecular Brain, 2015 - Springer
Background Nr2e1 is a nuclear receptor crucial for neural stem cell proliferation and
maintenance. In the retina, lack of Nr2e1 results in premature neurogenesis, aberrant blood …
maintenance. In the retina, lack of Nr2e1 results in premature neurogenesis, aberrant blood …
Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb
A Tsutiya, H Watanabe, Y Nakano… - Journal of …, 2016 - Wiley Online Library
Collapsin response mediator protein 4 (CRMP 4), a member of the CRMP family, is involved
in the pathogenesis of neurodevelopmental disorders such as schizophrenia and autism …
in the pathogenesis of neurodevelopmental disorders such as schizophrenia and autism …
Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing
JF Schmouth, RJ Bonaguro, X Corso-Diaz… - PLoS …, 2012 - journals.plos.org
An increasing body of literature from genome-wide association studies and human whole-
genome sequencing highlights the identification of large numbers of candidate regulatory …
genome sequencing highlights the identification of large numbers of candidate regulatory …
Nr2e1 Downregulation is involved in excess retinoic acid-induced developmental abnormality in the mouse brain
Objective This study aimed to investigate the expression pattern and function of Nuclear
receptor subfamily 2 group E member 1 (Nr2e1) in retinoic acid (RA)-induced brain …
receptor subfamily 2 group E member 1 (Nr2e1) in retinoic acid (RA)-induced brain …