Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core
set of genes that establish and maintain this neurotransmitter phenotype and distinguish …

Serotonin (5-HT) shapes brain networks during development and modulates a wide
spectrum of essential neuronal functions ranging from perception and cognitive appraisal to …

Serotonin neurons of the dorsal and median raphe nuclei (DR, MR) collectively innervate
the entire forebrain and midbrain, modulating diverse physiology and behavior. To gain a …

New genetic models that target the serotonin system show that transient alterations in
serotonin homeostasis cause permanent changes to adult behaviour and modify the fine …

Transgenic mouse lines are characterized with Cre recombinase driven by promoters of
CNS-specific genes using bacterial artificial chromosome (BAC) constructs. BAC-Cre …

Breathing is an essential behavior that presents a unique opportunity to understand how the
nervous system functions normally, how it balances inherent robustness with a highly …

The Ets family of transcription factors characterized by an evolutionarily-conserved DNA-
binding domain regulates expression of a variety of viral and cellular genes by binding to a …

Autism spectrum disorder (ASD) affects up to 1 in 59 individuals. Genome-wide association
and large-scale sequencing studies strongly implicate both common variants,–and rare de …

Transcription factors involved in the specification and differentiation of neurons often
continue to be expressed in the adult brain, but remarkably little is known about their late …

Serotonergic (5HT) neurons modulate diverse behaviors and physiology and are implicated
in distinct clinical disorders. Corresponding diversity in 5HT neuronal phenotypes is …