Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

Objectives To provide a clinical laboratory perspective on the Verifying Accurate Leading-
edge IVCT Development Act (VALID) discussion draft. This potential legislative effort, if …

PURPOSE An ASCO provisional clinical opinion offers timely clinical direction to ASCO's
membership following publication or presentation of potentially practice-changing data from …

Tandem mass spectrometry (MS/MS) is the most universal platform currently available for
the analysis of enzymatic activities and biomarkers in dried blood spots (DBS) for …

Pathologists are responsible for selecting the assays for the optimal identification of patients
for targeted therapy. The current paradigm of regulatory assay approval is that when a …

Unlocking the full potential of pathology data by gaining computational access to histological
pixel data and metadata (digital pathology) is one of the key promises of computational …

Simple Summary Patients and clinicians often rely on the outcome of laboratory tests, but
can we really trust these test results? Good quality management is key for laboratories to …

There has been a rapid uptick in the pace of oncology precision medicine advancements
over the past several decades as a result of increasingly sophisticated technology and the …

Context.—Next-generation sequencing–based assays are being increasingly used in the
clinical setting for the detection of somatic variants in solid tumors, but limited data are …

Abstract Zinc finger protein 180 (ZNF180) is a multifunctional protein that interacts with
nucleic acids and regulates various cellular processes; however, the function of ZNF180 in …