The prediction of protein three-dimensional structure from amino acid sequence has been a
grand challenge problem in computational biophysics for decades, owing to its intrinsic …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

Proximity labeling catalyzed by promiscuous enzymes, such as TurboID, have enabled the
proteomic analysis of subcellular regions difficult or impossible to access by conventional …

Red light penetrates deep into mammalian tissues and has low phototoxicity, but few
optogenetic tools that use red light have been developed. Here we present MagRed, a red …

Compartmentation of proteins into biomolecular condensates or membraneless organelles
formed by phase separation is an emerging principle for the regulation of cellular processes …

Advances in protein design have brought us within reach of developing a nanoscale
programming language, in which molecules serve as operands and their conformational …

There is a growing interest in the development of technologies to probe and direct in vitro
cellular function for fundamental organoid and stem cell biology, functional tissue and …

Splitting bioactive proteins into conditionally reconstituting fragments is a powerful strategy
for building tools to study and control biological systems. However, split proteins often …

Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable
programmable RNA editing, however their exogenous delivery leads to transcriptome-wide …

Chimeric antigen receptor T cell therapies have achieved great success in eradicating some
liquid tumors, whereas the preclinical results in treating solid tumors have proven less …