Recent advances in nanotherapeutic strategies for spinal cord injury repair

YH Song, NK Agrawal, JM Griffin, CE Schmidt - Advanced drug delivery …, 2019 - Elsevier
Spinal cord injury (SCI) is a devastating and complicated condition with no cure available.
The initial mechanical trauma is followed by a secondary injury characterized by …

Restoring sensorimotor function through neuromodulation after spinal cord injury: progress and remaining challenges

H Zhang, Y Liu, K Zhou, W Wei, Y Liu - Frontiers in Neuroscience, 2021 - frontiersin.org
Spinal cord injury (SCI) is a major disability that results in motor and sensory impairment and
extensive complications for the affected individuals which not only affect the quality of life of …

Epidural optogenetics for controlled analgesia

RP Bonin, F Wang, M Desrochers-Couture… - Molecular …, 2016 - journals.sagepub.com
Background Optogenetic tools enable cell selective and temporally precise control of
neuronal activity; yet, difficulties in delivering sufficient light to the spinal cord of freely …

Methane suppresses microglial activation related to oxidative, inflammatory, and apoptotic injury during spinal cord injury in rats

WH Wang, X Huang, J Li, A Sun, J Yu… - Oxidative Medicine …, 2017 - Wiley Online Library
Objective. We investigated the hypothesis that methane‐rich saline (MS) can be used to
repair spinal cord injury (SCI) in a rat model through suppressing microglial activation …

[HTML][HTML] Improved locomotor recovery in a rat model of spinal cord injury by BioLuminescent-OptoGenetic (BL-OG) stimulation with an enhanced luminopsin

EC Ikefuama, GE Kendziorski, K Anderson… - International Journal of …, 2022 - mdpi.com
Irrespective of the many strategies focused on dealing with spinal cord injury (SCI), there is
still no way to restore motor function efficiently or an adequate regenerative therapy. One …

Advances in Optogenetics applications for central nervous system injuries

Y Geng, Z Li, J Zhu, C Du, F Yuan, X Cai, A Ali… - Journal of …, 2023 - liebertpub.com
Injuries to the central nervous system (CNS) often lead to severe neurological dysfunction
and even death. However, there are still no effective measures to improve functional …

On the development of optical peripheral nerve interfaces

HE Anderson - Neural Regeneration Research, 2019 - journals.lww.com
Limb loss and spinal cord injury are two debilitating conditions that continue to grow in
prevalence. Prosthetic limbs and limb reanimation present two ways of providing affected …

Neuroprosthesis Devices Based on Micro‐and Nanosensors: A Systematic Review

J Gutiérrez-Martínez, C Toledo-Peral… - Journal of …, 2020 - Wiley Online Library
Background. A neuroprosthesis (NP) is a medical device that compensates and restores
functionality of neural dysfunctions affected by different pathologies and conditions. To this …

Imaging of electrical activity in small diameter fibers of the murine peripheral nerve with virally-delivered GCaMP6f

HE Anderson, AK Fontaine, JH Caldwell, RF Weir - Scientific Reports, 2018 - nature.com
Current neural interfaces are hampered by lack of specificity and selectivity for neural
interrogation. A method that might improve these interfaces is an optical peripheral nerve …

Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation

Y Zeng, N Wang, T Guo, Q Zheng, S Wang… - Frontiers in …, 2018 - frontiersin.org
Sorting nexin 27 (SNX27) is an endosome-associated cargo adaptor that is involved in
various pathologies and development of neurological diseases. However, the role of SNX27 …