Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

Ghrelin, an acylated upper gastrointestinal peptide, is the only known orexigenic hormone.
Considerable evidence implicates ghrelin in mealtime hunger and meal initiation …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates
during fetal development. The pancreas develops through simple budlike structures on the …

Recently, it was demonstrated that pancreatic new-born glucagon-producing cells can
regenerate and convert into insulin-producing β-like cells through the ectopic expression of …

Background & Aims Acinar to ductal metaplasia (ADM) occurs in the pancreas in response
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …

The development of insulin-producing pancreatic beta (β)-cells represents the culmination of
a complex developmental program. Cells of the posterior foregut assume a pancreatic …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

Pancreatic endocrine cell differentiation depends on transcription factors that also contribute
in adult insulin and glucagon gene expression. Islet cell development was examined in mice …

Aristaless-related homeobox (Arx) was recently demonstrated to be involved in pancreatic α
cell fate specification while simultaneously repressing the β and δ cell lineages. To establish …