The mitochondrial pyruvate dehydrogenase complex (PDC) irreversibly decarboxylates
pyruvate to acetyl coenzyme A, thereby linking glycolysis to the tricarboxylic acid cycle and …

Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …

Understanding brain energy metabolism—neuroenergetics—is becoming increasingly
important as it can be identified repeatedly as the source of neurological perturbations …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Decidualization is an intricate biological process in which extensive remodeling of the
endometrium occurs to support the development of an implanting blastocyst. However, the …

Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of
lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta …

Actively dividing cells, including some cancers, rely on aerobic glycolysis rather than
oxidative phosphorylation to generate energy, a phenomenon termed the Warburg effect …

Preeclampsia (PE) is a leading cause of maternal and neonatal mortality and morbidity
worldwide, impacting the long‐term health of both mother and offspring. PE has long been …

Infertility is a worldwide reproductive health problem and there are still many unknown
etiologies of infertility. In recent years, increasing evidence emerged and confirmed that …