The gut-microbiome has been hypothesised as a novel potential target for intervention for
schizophrenia. We tested this hypothesis with a systematic review and meta-analysis of …

The fetal origin of adult disease hypothesis postulates that a stressful in utero environment
can have deleterious consequences on fetal programming, potentially leading to chronic …

Importance The endocannabinoid system (ECS) is a lipid-based endogenous signaling
system. Its relevance to psychosis is through the association between cannabis use and the …

Introduction Obesity and dyslipidemia may negatively affect brain health and are frequent
medical comorbidities of schizophrenia and related disorders. Despite the high burden of …

Anhedonia and amotivation are debilitating symptoms and represent unmet therapeutic
needs in a range of clinical conditions. The gut-microbiome-endocannabinoid axis might …

Our previous study showed that metabolic abnormalities reduced the levels of brain-derived
neurotrophic factor (BDNF) and deteriorated cognitive performance in patients with …

Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) are the most
implemented methodologies to detect alterations of both gray and white matter (WM) …

Background Metabolic abnormalities and peripheral inflammation have been increasingly
reported in patients at the onset of psychosis and associated with important physical health …

Objective We aimed to assess the prevalence and course of metabolic syndrome (MetS) and
the associated metabolic parameters during the year following a first episode pf psychosis …

Background Obesity is up to 4 times higher in patients with schizophrenia than in the
general population. However, the link between obesity and schizophrenia in the absence of …